Gelatin hollow capsules have stomach-soluble and enteric-coated hollow capsule. So we can learn about stomach-soluble hollow capsules application. In order to use it better later.
Name | Gelatin Capsule | Vegetarian Capsule |
Material | 100% Bone Glue | 100% Hypromellose |
Heavy Metal Content | <40-50ppm | <20ppm |
Preservative | Free | Free |
Storage Temperature | 10-25℃ | 10-40 ℃ |
Low Temperature | Brittle Broken | Stable |
High Temperature | Flexible Softening | Stable |
Storage Humidity | 35-65% | 35-65% |
Filling Rate | 99.9% | >99.9% |
Suitable Crowd | Except vegetarian Judaism Islam | All kinds of people |
Shelf Life | 24 months | 36 months |
The stomach-soluble hollow capsules has an outer shell containing active ingredients and fillers. The internal ingredients must be in the form of a liquid, paste or suspension, in which small particles of the active ingredient are suspended in the liquid. The shell is made of gelatin, usually from beef or pork, and plasticizers such as water and glycerin to provide durability and flexibility. Stomach dissolving capsule shells are beneficial to both drug and supplement manufacturers and consumers.
Capsule shell quick sol method and its equipment manufacturing method. Gelatin liquid is needed to make the capsule shell. The gelatin liquid should not have bubbles in the gelatin liquid during use, otherwise it will affect the appearance of the capsule shell and the quality of the product. Therefore, the air needs to be removed during the production process to prevent the air from entering during the storage process. The traditional method has the problems of long production time of gelatin liquid and long storage and degassing time. At the same time, the quality of gelatin liquid is affected by the long time for producing and storing the degassing of gelatin liquid. Our purpose is to provide a fast sol method for capsule shells, the gelatin liquid preparation time is short, and the prepared gelatin liquid is of good quality.
Turn on the heating device to heat the sol unit, and add solid materials to the sol unit. After the solid materials are added, the sol unit is vacuumed. The preheated pure water in the purified water unit is added to the sol unit, and the vacuum in the sol unit is maintained. Add glycerin to the sol unit. Turn on the stirrer in the sol unit to melt the solid materials in the sol unit to form a gelatin liquid, and maintain the vacuum in the sol unit. When the stirring time reaches the predetermined time, the stirring is stopped, and the water vapor generated in the sol unit is pumped out. When the pumping reaches the predetermined value, the vacuuming is stopped. The gelatin liquid in the sol unit is transferred to the thermal insulation transfer unit.
By adopting the above technical scheme, the fixed material is added first and then the pure water is added, and the solid material is covered by the pure water. When there is air in the sol unit, it will not enter the gelatin liquid. The solid materials in the feeding step include gelatin powder and pigments for making capsules. After the solid materials are added, vacuum the sol unit to extract the air mixed in the solid materials, so as to avoid the air in the solid materials from being mixed into the gelatin liquid to form bubbles. Since the pure water is preheated, the time for the heating device to heat the sol unit is reduced, and the production efficiency is improved. After the pure water and glycerin are added, the sol unit needs to be evacuated to remove the air in the material and prevent the air in the material from turning into bubbles in the gelatin liquid.
Compared with the removal of air bubbles in the gelatin liquid in the traditional method, the effect of vacuuming and degassing the material is better, and the removal efficiency is higher. Vacuum is applied during the stirring process to prevent the air in the sol unit from being mixed into the gelatin liquid. Since each addition of materials is vacuum degassed, there are very few bubbles in the gelatin liquid after the preparation is completed. The problems of difficult degassing and long degassing time in the prior art are solved, and the preparation efficiency is improved while ensuring the quality of the gelatin liquid.
Drugs are usually packed directly into the capsule shell in the form of powder or granules, unlike tablets that are affected by factors such as pressure during tablet preparation. Therefore, it is rapidly dispersed, dissolved and absorbed in the gastrointestinal tract, and its bioavailability is higher than that of pills and tablets. The disintegration time of capsules is within 30 minutes, while that of tablets and pills is within 1 hour.
Capsules can also improve the stability of the drug. Because the drug is contained in the capsule shell and is isolated from the outside world, it can shield, protect and stabilize unstable drugs to a certain extent. When taking capsules, some people feel that the capsule shell is redundant, or feel that the capsule shell is large and difficult to swallow, so they take the medicine by discarding the capsule. This is not correct. Most capsules should be swallowed whole.
The capsule shell is made of medicinal gelatin, which is soluble in water and gastric acid and is harmless to the human body. Secondly, some of the medicines packed in capsules are irritating to the esophagus and gastric mucosa, and some are easy to volatilize. Removing the capsule shell may cause the loss of the medicine and reduce the efficacy of the medicine. Especially non-steroidal anti-inflammatory drugs, direct use may cause gastric mucosal damage. When taking capsules, some people feel that the capsule shell is redundant, or feel that the capsule shell is large and difficult to swallow, so they take the medicine by discarding the capsule. This is not correct. Most capsules should be swallowed whole.
The gelatin of the capsule shell is a substance that slowly absorbs water in cold water and becomes soft, but quickly dissolves in hot water. If you eat the capsule with too much hot water, the capsule will become soft and sticky. If you don’t drink enough water, it may stick to the esophagus. In the case of gastric-soluble capsules, hot water will destroy the capsule’s resistance to gastric juice, preventing the medicine that should be protected from passing through the stomach to the intestine. Therefore, cold water and warm water should be used to eat capsules, but not hot water.
XIAMEN HUAXUAN GELATIN CO.,LTD have started to supply gelatin granule and hard empty capsule to different countries from 2006.
Rihua building, Huli District, Xiamen, Fujian, CN. Mon-Fri 08:00 AM – 05:00PM
+8618959273323 (24/7 Emergency)
Email: xiaoqiang@hx-gelatin.com